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apalutamide will lessen the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs which can be CYP3A4 substrates may result in lessen exposure to those remedies.Making use of this medication with any of th